2017 Fiscal Year Final Research Report
Exhaustive gene expression analysis after transarterial chemoembolization by DNA microarrays
| Project/Area Number |
25861093
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Osaka International Cancer Institute (2016-2017)
Osaka University (2013-2015) |
|---|
Principal Investigator |
Maeda Noboru 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 放射線診断・IVR科副部長 (00506488)
|
|---|
| Project Period (FY) |
2013-04-01 – 2018-03-31
|
| Keywords | DNAマイクロアレイ / 動脈塞栓術 / 化学塞栓療法 / 薬剤溶出性塞栓物質 / 肝癌 / エピルビシン / 高吸水性ポリマー / リピオドール |
|---|
| Outline of Final Research Achievements |
The purpose of this study was to compare gene expression in rabbit liver after conventional transarterial chemoembolization with Lipiodol (Lip-TACE) to that after transarterial chemoembolization with drug-eluting microspheres (DEB-TACE) by DNA-microarray technique. There were differences about gene expression both in a kind of chemoembolization and number of days after chemoembolization. This result suggested that gene expression after transarterial chemoembolization was possibly related to the dysfunction of non-tumorous liver parenchyma and the local control mechanism to the tumor by chemoembolization.
|
| Free Research Field |
医歯薬学
|
