Assessment of impaired microcirculation by BOLD MR imaging during reactive hyperemia

2015 Fiscal Year Final Research Report

• Project/Area Number: 25861102
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kobe University
• Principal Investigator: Kono Atsushi 神戸大学, 医学部附属病院, 講師 (20574388)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: BOLD / 微小循環 / 磁気共鳴画像 / magnetic resonance

Outline of Final Research Achievements

Assessment of muscle blood flow response (MFR) by dynamic muscle blood oxygen level-dependent (BOLD) magnetic resonance (MR) imaging is unknown. First, we developed the method to assess BOLD effect in the muscle by using 3 tesla MR and performed its validation with a new developed in-house software. Second, we investigated the effect of smoking on vascular function according to MFR during postocclusive reactive hyperemia in young smokers and nonsmokers. We underwent BOLD imaging in sixteen healthy male volunteers. The 2 key mBOLD variables such as times to half hyperemic peak (T1/2peak) and times to peak (TTP) were evaluated. This study showed that T1/2peak and TTP were significantly longer in smokers in reactive hyperemia. Dynamic BOLD MR imaging of calf muscle during postocclusive reactive hyperemia demonstrated statistically significant differences in T1/2peak and TTP between young smokers and nonsmokers, indicating the presence of early stage smoking-related deterioration in MFR.

Free Research Field

放射線医学