The development of the method of four-dimensional radiation treatment planning based on the time-dependent radiobiological model

2014 Fiscal Year Final Research Report

• Project/Area Number: 25861105
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Okayama University
• Principal Investigator: OITA Masataka 岡山大学, 保健学研究科, 准教授 (10380023)
• Research Collaborator: UTO Yoshihiro 徳島大学, 大学院ソシオテクノサイエンス研究部, 教授 ; TOMINAGA Masahide 徳島大学, 大学院医歯薬学研究部, 助教 ; KATSUI Kuniaki 岡山大学, 助教 ; KATAYAMA Norihisa 岡山大学, 助教
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 放射線治療物理学 / 時間放射線生物学 / 4次元放射線治療 / 放射線感受性 / 線量不均一性 / 細胞不均質 / 照射マージン

Outline of Final Research Achievements

The aim of this study was to develop the circumstances of simulation of the methods of treatment planning which was considered with time-dependent(4D) radiobiological response of tumor cells in radiotherapy. Applying for this model into the treatment planning system, we have developed the analysis of the radiobiological effect of the cancer treatment in radiotherapy, such as the delay effect in 4D-RT, the effect of dose inhomogeneities in IMRT and the effect of variation of radiation sensitivity and inhomogeneities of cells. As a results of premitive simulation, we have found that those dosimetric inhomogeneities and tumor inhomogeneities and variations of radiation sensitivity were involved in the treatment field margins and predictions of cell survivals. In this study, it was expected that we could develop these biological uncertainties for clinical radiation treatment planning with this biological model.

Free Research Field

放射線治療物理学