2014 Fiscal Year Final Research Report
Development of stable and high-precision receptor concentration analysis method based on simplified pharmacokinetic model
| Project/Area Number |
25861123
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 分子イメージング / 薬物動態解析 / 脳・神経 / 核医学 / 放射線 |
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| Outline of Final Research Achievements |
A novel estimation method which allows PET acquisition after administration certain time without the arterial blood sampling was proposed in this study.
The proposed method is a kind of graphical analysis such as Logan plot, constructed a new model represented a tissue time-activity curve after a certain time from drag administration by a linear sum of three exponential function. Moreover, the rate constants were estimated by Laguerre polynomial approximation, and then calculated the total volume of distribution and receptor binding potential.
The proposed method was sensitive noise of image, and estimated variance was significantly greater compared with other estimation methods.
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| Free Research Field |
核医学, 医用画像工学
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