2015 Fiscal Year Final Research Report
Development of an imaging probe to estimate protoporphyrin IX accumulation induced by aminolevulinic acid
| Project/Area Number |
25861136
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Hamamatsu University School of Medicine (2015)
National Institute of Radiological Sciences (2013-2014) |
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Principal Investigator |
Suzuki Chie 浜松医科大学, 光尖端医学教育研究センター, 助教 (20637285)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 核医学 / PET / アミノレブリン酸 / C-11 |
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| Outline of Final Research Achievements |
C-11 labeled aminolevulinic acid derivative ([C-11]MALA) was developed as an imaging prove to estimate tumor protoporphyrin IX (PpIX) accumulation indecued by exogenous aminolevulinic acid (ALA). Tumor accumulation of [C-11]MALA was correlated with that of PpIX induced by ALA, suggesting that [C-11]MALA-PET has the potential to estimate ALA-induced PpIX accumulation.
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| Free Research Field |
放射線医薬品化学
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