2014 Fiscal Year Final Research Report
Analysis of cancer immune evasion through induction of steroid like agent, GITRL against NK cells
| Project/Area Number |
25861156
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | ＮＫ細胞 / 癌免疫 / ステロイド |
|---|
| Outline of Final Research Achievements |
Cancer might alter microenvironment to enable immune escape. To investigate how HCC got immune evasion through GITRL in human HCC, we analyzed the phenotype of liver NK cells and effect of GITRL on NK cells. GITRL released from HCC were shown to suppress NK cell activity in vitro. Liver NK cells expressed more GITRL receptor, GITR than peripheral blood NK cells did. Interestingly, HCC patients had very low level of GITR expression on liver NK cells. Exposure to inflammatory cytokine upregulated GITR expression on liver NK cells. These findings suggest that the effect of GITRL on NK cells might manipulate microenvironment for cancer cells to evade immune system.
|
| Free Research Field |
消化器・移植外科学
|
