2014 Fiscal Year Final Research Report
Phosphatome-constitution predisposed to breast cancer
| Project/Area Number |
25861168
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
|
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| Research Institution | Miyagi Prefectural Hospital Organization Miyagi Cancer Center |
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Principal Investigator |
FUKAMACHI KAYOKO 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (00626137)
|
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | 乳がん / HER2 / ホスファターゼ / BRCA1 / PP6 / SNPs / ノックアウトマウス / 発がん実験 |
|---|
| Outline of Final Research Achievements |
Dysregulation of HER2 and BRCA1 phosphorylation are thought to be causes of mammary carcinogenesis. As PP6, one of protein phosphatase, was thought function in this process, we analyzed role of PP6 in carcinogenesis in mice. We found that abrogation of PP6 promotes skin carcinogenesis induced by DMBA.
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| Free Research Field |
医歯薬学
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