Trial to identify the bacteria which causes ulcerative colitis on the hypothesis that pouchitis is ulcerative ileitis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25861171
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Tohoku University
• Principal Investigator: Kohyama Atsushi 東北大学, 医学(系)研究科(研究院), 非常勤講師 (50647005)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 潰瘍性大腸炎 / 回腸嚢炎 / 腸内細菌叢 / 家族性大腸腺腫症

Outline of Final Research Achievements

Pouchitis is a major late complication which sometimes occurs after restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA). However, its pathogenesis still remains unclear. The rate of incidence is higher in ulcerative colitis’cases and quite rare in familial adenomatous polyposis' cases. Furthermore, the fact that antibiotics and probiotics are effective in treating pouchitis indicates a direct or indirect link of pouch microbiota to mucosal inflammation.
There are two aims based on the hereditary background to elucidate how microbiota in the guts alter after the patients’ operation and what causes the inflammation in the ileum, which is not supposed to have any lesions in the ulcerative colitis.
In addition, the other aim is to investigate the pathogenesis which causes ulcerative colitis according to the hypothesis that “pouchitis is ulcerative ileitis."

Free Research Field

消化器外科