Does the degree of hepatic ischemia reperfusion injury differ depending on the cause of fatty liver?

2014 Fiscal Year Final Research Report

• Project/Area Number: 25861182
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Mie University
• Principal Investigator: FUJII Takehiro 三重大学, 医学(系)研究科(研究院), リサーチアソシエイト (00640690)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 肝虚血再灌流傷害 / 脂肪肝 / 肝移植 / 術後合併症 / トロンボモジュリン / 治療薬 / 白血球浸潤 / 肝細胞壊死

Outline of Final Research Achievements

We investigated the difference of hepatic ischemia reperfusion injury(IRI) between the fatty liver of mice caused by fat and by fructose. The results suggested more serious vulnerability to IRI in the fatty liver caused by fructose than by fat. Our present study also showed that thrombomodulin agent reduced the IRI in the fatty liver caused by fat inhibiting leukocyte invasion in injured liver.

Free Research Field

肝虚血再灌流障害