2014 Fiscal Year Final Research Report
Development of novel therapies that focus on specific stroma cell induced peritoneal dissemination of pancreatic cancer
| Project/Area Number |
25861198
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | 膵癌 / 筋線維芽細胞 / 腹膜播種 / 癌間質相互作用 |
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| Outline of Final Research Achievements |
This study was designed to assess the role of myofibroblasts at peritoneally disseminated sites of pancreatic cancer. Human peritoneal myofibroblasts (hPMFs) were established from disseminated sites of pancreatic cancer and their interactions with the SUIT-2 and CAPAN-1 human pancreatic cancer cell lines were analyzed in vitro and in vivo. In vitro, hPMFs significantly promoted the migration and invasion of pancreatic cancer cells (P<0.05), while the cancer cells significantly promoted the migration and invasion of hPMFs (P<0.05). In vivo, the number of perito-neally disseminated nodules was significantly greater in mice implanted with cancer cells plus hPMFs compared to mice implanted with cancer cells alone.
HPMFs promote the peritoneal dissemination of pancreatic cancer. The cancer-stromal cell interaction in the peritoneal cavity may be a new therapeutic target to prevent the dissemination of pancreatic cancer.
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| Free Research Field |
医歯薬学
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