2014 Fiscal Year Final Research Report
FOSB and c-Fos which constitute AP-1 expressed in the bone marrow at the advanced gastric cancer patients
| Project/Area Number |
25861200
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Kumamoto University (2014)
Kyushu University (2013) |
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Principal Investigator |
KURASHIGE junji 熊本大学, 医学部附属病院, 特任助教 (90594474)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | AP-1 / c-FOS / FOSB / gastric cancer |
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| Outline of Final Research Achievements |
The expression levels of c-FOS and the FOSB in bone marrow and peripheral blood in was examined using 200 resected specimens to determine the clinicopathological significance. The expression levels of c-FOS and the FOSB were determined by qRT-PCR. The immunohistochemical studies for c-FOS were performed on formalin-fixed paraffin-embedded surgical sections obtained from 150 patients with gastric cancer. We also investigated the role of c-Fos and FOSB in the regulation of in vivo analysis.
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| Free Research Field |
消化器外科学
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