2014 Fiscal Year Final Research Report
Pancreatic stellate cells specific HSP47 genetic control promote pancreatic regeneration
| Project/Area Number |
25861207
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
OTA Shigenori 札幌医科大学, 医学部, 研究員 (90457705)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 膵再生 / 膵星細胞 / 再生医療 / HSP47 / 薬物輸送システム |
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| Outline of Final Research Achievements |
Pancreatic acinar cells(Pacs) and Islet cells(Ics) vigorously proliferated after 90% pancreatectomy. In addition, Pacs proliferation was facilitated by co-culture with pancreatic stellate cells(Pscs). HSP 47 activation in Pscs plays an important role in the proliferation of Pacs, which was totally blocked by HSP47-specific siRNA delivery in vivo and in vitro. Therefore, HSP47 expression in Pscs would be necessary to promote pancreatic regeneration.
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| Free Research Field |
医歯薬学
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