2014 Fiscal Year Final Research Report
Role of extrahepatic cells in liver regeneration
| Project/Area Number |
25861212
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | 肝再生 / 肝外細胞 / 門脈圧 / 脾摘 |
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| Outline of Final Research Achievements |
Extrahepatic cells have been considered a potential cellular resource for liver regeneration in response to liver damages. The genotyping of human living donor liver transplant recipients has reported that cells derived from those recipients of living donor liver transplantation differentiated into multiple types of liver component cells, suggesting that extrahepatic, as well as multipotent, cells contributed to liver regeneration.
Excessive portal vein pressure have been considered a disadvantage factor for liver regeneration. We measured portal vein pressure and liver volume simultaneously. That result show that just after splenectomy portal vein pressure didn’t go down but one week after operation portal vein pressure went down and liver regeneration was increasing than not splenectomy group. Splenectomy can avoid excessive portal vein pressure and promote liver regeneration at excessive liver resection or liver transplantation.
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| Free Research Field |
肝再生
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