Examination of ONO-1301 for inhibitory effect of paravalvular leak following transcatheter aortic valve implantation

2014 Fiscal Year Final Research Report

• Project/Area Number: 25861228
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular surgery
• Research Institution: Osaka University
• Principal Investigator: MAEDA Koichi 大阪大学, 医学部附属病院, 特任助教 (50644994)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 弁周囲逆流

Outline of Final Research Achievements

The aim of this study was to examine the inhibitory effects of ONO-1301 for paravalvular leak following transcatheter aortic valve implantation. The stent grafts with gelatin hydrogel including ONO-1301 and bone fragment, were implanted on the aorta on HBD dogs. The paravalvular leak was reduced over time until one month, but, was unchanged after one month. The histology revealed the fibrous tissue and intimal proliferation between the aorta and the bone fragment. ONO-1301 may be useful to prohibit paravalvular leak following transcatheter aortic valve implantation.

Free Research Field

心臓血管外科