2015 Fiscal Year Final Research Report
The study of obliterans bronchiolitis immunopathogenisis and therapy after lung transplant.
Project/Area Number |
25861240
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Respiratory surgery
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Research Institution | Chiba University |
Principal Investigator |
Suzuki Hidemi 千葉大学, 医学(系)研究科(研究院), 助教 (60422226)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Keywords | 肺移植 / 拒絶反応 / 肺再生 / 自己免疫 |
Outline of Final Research Achievements |
Due to no effective therapies for obliterative bronchiolitis(OB), the leading cause of death in lung transplant patients, there has been an intensive search for pre-clinical models that replicate OB. We initiated the OB model using minor histoincompatible antigen murine orthotopic single-left lung transplants. We reported that minor, but not major, histocompatibility antigens account for the 50% rate of OB after 28 day after transplant in murine orthotopic lung transplants. IL-10 induction was associated with the absence of OB, whereas, OB development was IL-17 dependent.Donor mice derived minor histoincompatible antigen contribute to OB development and IL-17 induction. Strategies to identifyminor histoincompatible antigen and prevent IL-17 induction in clinical lung transplantation could be useful to reduce the risk of OB development.
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Free Research Field |
呼吸器外科
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