2014 Fiscal Year Final Research Report
How cancer cells condition fibroblasts for metastasis with them?
| Project/Area Number |
25861249
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Research Collaborator |
HATO Tai 慶應義塾大学, 医学部, 助教 (10365281)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 肺癌 / 共培養 / 線維芽細胞 / 細胞集塊型転移 |
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| Outline of Final Research Achievements |
1) As a result of co-culture of cancer cells and fibroblasts, their form was changed in a strange morphology. 2) As a result of co-culture of cancer cells and fibroblasts, cell proliferation activity and anti-apoptotic activity was shown to increase. 3) As a result of co-culture of cancer cells and fibroblasts, anti-cytotoxic drug resistance was increased. But they not effect for resistance to EGFR-TKIs.4) As a result of co-culture of cancer cells and fibroblasts, the expression of angptl4 in them was enhanced, but the detailed mechanism is necessary to examine.5)We tried to create the in vivo model to examine the relevance of spheroid co-culture for metastasis
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| Free Research Field |
呼吸器外科、癌
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