2014 Fiscal Year Final Research Report
Functional analysis of S100A14 in the invasion and metastasis of lung cancer
| Project/Area Number |
25861252
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory surgery
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| Research Institution | Keio University (2014)
Shizuoka Cancer Center Research Institute (2013) |
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Principal Investigator |
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| Research Collaborator |
SUGINO Takashi 静岡県立静岡がんセンター, 研究所, 研究員 (90171165)
WAKUI Masatoshi 慶應義塾大学, 医学部, 講師 (90240465)
MORI Tsutomu 福島県立医科大学, 看護学部, 准教授 (60244373)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 原発性肺癌 |
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| Outline of Final Research Achievements |
Clinical data showed that S100A14 in lung cancer tumor may be one of the prognostic factor.
Human lung cancer cell line, QG56 cells, was used for the in vitro analysis. In S100A14-knocked down QG56 cells, the abilities of cell proliferation, cell invasion, and cell migration were evaluated. The assays showed that the abilities of cell invasion and of cell migration were significantly diminished, however the ability of cell proliferation was not changed significantly. The analysis of signal pathway related to S100A14 showed that the weakening of MAPK was revealed, induced by the inhibition of S100A14.
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| Free Research Field |
呼吸器外科
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