Basic research of the origin of malignant brain tumor by molecular cell biological techniques.

2016 Fiscal Year Final Research Report

• Project/Area Number: 25861259
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Kudo Takumi 東京医科歯科大学, 医学部附属病院, 助教 (90632125)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 膠芽腫 / RASSF3 / 腫瘍抑制因子

Outline of Final Research Achievements

we analyzed the function of one of a tumor suppressor, ras-association domain family(RASSF)3, in glioblastoma. The expression analysis of RASSF3 in glioma showed the clinical involvement of RASSF3 expression in terms of the tumor grade and overall survival as well. We established a primary cell culture, glioma stem cell, from the tumor tissue of glioblastoma which was resected in the operation. The functional analysis of RASSF3 with molecular cell biological technique showed that RASSF3 over expression resulted in apoptosis induction. RASSF3 reduction resulted in the impairment of induced apoptosis and promotion of cell proliferation.
These results suggested that RASSF3 functions as a tumor suppressor in glioblastoma.

Free Research Field

脳神経外科