2015 Fiscal Year Final Research Report
The role of a novel platelet activated receptor CLEC-2 in the carotid plaque
| Project/Area Number |
25861265
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 頚動脈プラーク / CLEC-2 / ポドプラニン / 頚部頚動脈狭窄症 / 不安定プラーク |
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| Outline of Final Research Achievements |
The vulnerability of the carotid plaque is strongly associated with cerebral infarction. However, the mechanism has not been elucidated. On the other hand, C-type lectin-like receptor 2 (CLEC2), a novel platelet activated receptor, is suggested to participate in the vulnerability of the atheromatous plaque, cooperating with its ligand podplanin. Immunohistochemical analysis indicated that podoplanin was localized to macrophages and smooth muscle cell in the intima of carotid artery. Vulnerable plaque by preoperative diagnostic MR plaque imaging and symptomatic lesions were more likely to express podoplanin.
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| Free Research Field |
脳神経外科
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