2014 Fiscal Year Final Research Report
Search to the future of the IV t-PA therapy
| Project/Area Number |
25861266
|
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| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
|
|---|
| Research Institution | Gifu University |
|---|
Principal Investigator |
|
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | t-PA静注療法 |
|---|
| Outline of Final Research Achievements |
As for the thrombolysis therapy using intravenous t-PA for the cerebral infarction, the treatable time is strictly limited within 3 hours after onset because of complications called cerebral hemorrhage. We showed that fasudil decreased the hemorrhagic transformation using a mouse model. It was shown that fasudil prevent hemorrhagic infarction by protecting vascular endothelium whereas t-PA itself had the toxicity for vascular endothelial cells. These results shows the possibility that treatable time of the cerebral infarction can be extended in the future.
|
| Free Research Field |
脳神経外科学
|
