Clarifying the pathophysiology of early brain injury after subarachnoid hemorrhage focusing on matricellular proteins.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25861272
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Mie University
• Principal Investigator: SHIBA Masato 三重大学, 医学部附属病院, 診療等従事者 (30595682)
• Research Collaborator: SUZUKI Hidenori ; FUJIMOTO Masashi ; KAWAKITA Fumihiro
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: くも膜下出血 / 早期脳損傷 / マトリセル蛋白 / テネイシンC / MAPキナーゼ

Outline of Final Research Achievements

We investigated the effect of tenascin-C(TNC), a matricellular protein, on pathophysiology of early brain injury after experimental subarachnoid hemorrhage(SAH) by using rats and mice endovascular perforation models. Firstly, we showed that SAH caused neuronal apoptosis in the brain with TNC upregulation. Next, we showed that intracisternally injected recombinant TNC reversed the anti-apoptotic effects in brain by imatinib. Lastly, using various inhibitors, we showed that early brain injury was improved with inhibition of TNC upregulation by supression of MAP kinase-dependent MMP-9 induction.

Free Research Field

脳血管障害