2014 Fiscal Year Final Research Report
Influence of astrocyte in traumatic brain injury
| Project/Area Number |
25861292
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | アストロサイト / 脳挫傷 / グリオトランスミッター |
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| Outline of Final Research Achievements |
In this study, we investigated if suppression of gliotransmitter potent therapeutic effect in a rat traumatic injury model. Rat cerebral contusion model was made and either cerebrospinal fluid or MRS2179, a selective P2Y1 blocker was in situ administrated. Galectin-3 was used as a marker of active microglia. Galectin-3 positive amoeboid microglia was observed mainly around the contused tissue from 1 day after injury. Administration of MRS2179 significantly suppressed the expression of Galectin-3 after day 3. MRS2179 injection improved some behavioral test score.
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| Free Research Field |
脳神経外科
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