2014 Fiscal Year Final Research Report
The significance of amino acid PET which considered blood perfusion in diagnosis of recurrent malignant brain tumor
Project/Area Number |
25861294
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurosurgery
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Research Institution | Osaka Medical College |
Principal Investigator |
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Research Collaborator |
KAWABATA Shinji 大阪医科大学, 医学部, 講師 (20340549)
FURUSE Motomasa 大阪医科大学, 医学部, 講師 (70340560)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Keywords | PET / glioma / 血液灌流 / 病態診断 |
Outline of Final Research Achievements |
I showed that 18F-BPA positron emission tomography (PET), using the essential amino acids “phenylalanine” as a PET tracer, was useful in the differentiation of the change after treatment such as recurrence of tumor or the radiation injury / necrosis during the course after malignant glioma treatment. However, there is not the definition that is yet clear for the interpretation of results obtained by the amino acid PET that we did including 18F-BPA. In the amino acid PET image, we should think that not only this diagnosis image shows tumor metabolism, but also is affected by tumor tissue blood perfusion. Furthermore, we devised analytical method to lead visualization of "the true amino acid metabolism" and investigated the usefulness about an evaluation and the pathologic diagnosis after treatment of the brain tumor with this technique.
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Free Research Field |
脳神経外科
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