2014 Fiscal Year Final Research Report
Development of drug delivery system for nerve repair
Project/Area Number |
25861309
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Orthopaedic surgery
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Research Institution | Nagoya University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Keywords | CMC-PE / TNF-α / nerve / pain |
Outline of Final Research Achievements |
The purpose of this study is to develop a novel drug delivery system for nerve repair. We have developed a novel sodium carboxymethylcellulose (CMC)-derived hydrogel in which phosphatidylethanolamine (PE) was introduced into the carboxyl groups of CMC. We used a rat model of chronic nerve compression with silicon tube in sciatic nerve. Biomechanical analysis to assess perineural adhesion, electrophysiological evaluation of motor nerve conduction velocity (MCV), wet muscle weight measurements (tibialis anterior), and histological evaluation, morphometric analysis were performed at 1, 2 and 3 months after removal of silicone tube. These results suggest that the gel enhanced axonal recovery after chronic nerve compression. The result of real time PCR showed that the gel reduced expression of inflammatory cytokines. The gel may become the useful material for the drug delivery system.
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Free Research Field |
整形外科学
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