2014 Fiscal Year Final Research Report
The functional analysis of perlecan in the late stage of osteophyte formation in knee osteoarthritis
| Project/Area Number |
25861343
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 変形性膝関節症 / 骨棘 / 滑膜 / 軟骨分化 / パールカン |
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| Outline of Final Research Achievements |
Osteophyte in knee osteoarthritis (knee OA) is formed from the mesenchymal cells present in the synovial membrane. The developmental process of osteophyte is similar to that of an endochondral ossification. However, it is still unclear their molecular mechanisms. Perlecan is a heparan sulfate proteoglycan present in the extracellular matrix of cartilage and synovium and is one of the essential factors for the cartilage development. The aim of this study was to investigate the role of perlecan expressed in the synovial membrane adjacent of the edge of articular cartilage in the late stage of osteophyte formation in knee OA. The absence of synovial perlecan suppressed the osteophyte formation in the late stage of knee OA. The results of the present study suggests that perlecan expressed in the synovial membrane promotes osteophyte formation in the late stage, in addition to the early stage, of knee OA.
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| Free Research Field |
変形性関節症
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