The effect of ketamine on natural killer cell cytotoxicity

2015 Fiscal Year Final Research Report

• Project/Area Number: 25861353
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Hirosaki University
• Principal Investigator: Hidetomo Niwa 弘前大学, 医学部附属病院, 助教 (20374845)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ケタミン / グリオーマ / NMDA受容体拮抗薬

Outline of Final Research Achievements

ketamine is very familiar with us since it is commonly used in radical surgery as an anesthetic agent. Unfortunately, even basic data on the anti-tumor effects of ketamine is lacking. In the present study, we found that ketamine induced cell death due to apoptosis, which resulted in suppressing the growth of glioma cells. We know that it may be difficult to apply the results of the basic study to human cases. But, in the current clinical practice, ketamine is the only viable anesthetic option among NMDAR antagonists, and it can be used in neurosurgery. Our results suggest that ketamine is an anesthetic candidate providing potential benefit for glioma resection. Our results suggest that ketamine is an anesthetic candidate providing potential benefit for glioma resection.

Free Research Field

麻酔科学