The effect of endoplasmic reticulum stress on neurotoxicity caused by inhalational anesthetics

2014 Fiscal Year Final Research Report

• Project/Area Number: 25861359
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Chiba University
• Principal Investigator: KOMITA Mari 千葉大学, 医学部附属病院, 助教 (90589194)
• Co-Investigator(Kenkyū-buntansha): AOE Tomohiko 千葉大学, 医学研究院, 准教授 (90311612)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 神経科学 / ストレス

Outline of Final Research Achievements

Background: The mechanisms by which inhalational anesthetics cause neurotoxicity are not well clarified. Since ER stress leads to cellular dysfunction and apoptotic cell death, leading to diverse human disorders such as neurodegenerative diseases, we hypothesized ER stress may play a role in neurotoxicity caused by inhalational anesthetics.
Results,Conclusions: Sevoflurane exposure cause ER stress, which is tolerated to some extent in the wild type cells. When this tolerance is limited, like in cells with mutant BiP, the exposure leads to cell death in the brain, indicating that ER stress may partially mediate neurotoxicity caused by inhalational anesthetics. This study conceivable that the patients with certain conditions sensitive to ER stress such as ischemia, hypoxia, developing brain or neurodegenerative diseases may be vulnerable to inhalational anesthetics.

Free Research Field

麻酔科学