The neuroprotective effect of bone marrow derived mesenchymal cells for neurotoxicity of neonatal sevoflurane exposure

2015 Fiscal Year Final Research Report

• Project/Area Number: 25861361
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Satomoto Maiko 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (10611551)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 麻酔 / 神経毒 / 学習 / 脳 / セボフフラン

Outline of Final Research Achievements

Neonatal exposure to anaesthetics such as sevoflurane has been reported to result in behavioural deficits in rodents. However, while oxidative injury is thought to play an underlying pathological role, the mechanisms of neurotoxicity remain unclear. In the present study, we investigated whether the NADPH oxidase inhibitor apocynin protects against long-term memory impairment produced by neonatal sevoflurane exposure in mice. Apocynin reduces neuronal apoptosis and protects against long-term memory impairment in mice neonatally exposed to sevoflurane by reducing superoxide levels. These findings suggest that NADPH oxidase inhibitors may protect against cognitive dysfunction resulting from neonatal anaesthesia.
Bone marrow derived mesenchymal cells cannot attenuate neurotoxicity induced by sevoflurane in reonatal rat.

Free Research Field

麻酔