2014 Fiscal Year Final Research Report
Effects of atropine on cerebrovascular function in rats.
| Project/Area Number |
25861370
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Gifu University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | アトロピン / 脳血管内皮機能 / 麻酔 |
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| Outline of Final Research Achievements |
We often give a cholinesterase inhibitor as an antagonism of the muscle relaxant at the time of awakening from general anesthesia, but giving atropine as anticholinergic agent is unavoidable for the purpose of inhibiting the muscarinic action that is a side effect. On the other hand, choline activity in the brain in the elderly people is relatively reduced, administraiton of the atropine may cause an awakening delay, disturbance of consciousness, or delirium. There was not a report about the effect of atropine on cerebrovascular function, so we evaluated it using the "Cranial Window method" . As a result, there was not able to confirm the influence on cerebrovascular function of atropine by our method.
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| Free Research Field |
麻酔学
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