2014 Fiscal Year Final Research Report
The role of GABAergic tonic inhibition in sustantia gelatinosa neuron of sciatic nerve chronic constriction injury model mice
| Project/Area Number |
25861374
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Osaka University |
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Principal Investigator |
TAKAHASHI Ayako 大阪大学, 医学(系)研究科(研究院), 助教 (70444544)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 神経障害性疼痛 / ＧＡＢＡＡ受容体 / tonic電流 / 脊髄 |
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| Outline of Final Research Achievements |
The present study demonstrated that sciatic nerve constriction (CCI) induced the decrease of GABAergic tonic current and GABAARs δ subunit expression in spinal dorsal horn. Improved understanding of GABAARs δ subunit may facilitate development of more effective treatment strategies for neuropathic pain.
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| Free Research Field |
麻酔
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