• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2014 Fiscal Year Final Research Report

Mechanisims of isoflurane-induced carrdiac protection from ischemia/reperfusion injury: a role for glucagon-like peptide-1.

Research Project

  • PDF
Project/Area Number 25861377
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Anesthesiology
Research InstitutionThe University of Tokushima

Principal Investigator

KAWANO Hiroaki  徳島大学, ヘルスバイオサイエンス研究部, 徳島大学特別研究員 (90467811)

Project Period (FY) 2013-04-01 – 2015-03-31
Keywordsイソフルラン / グルカゴン様ペプチドー1 / プレコンディショニング / 心筋保護作用
Outline of Final Research Achievements

To assess the role of volatile anesthetic (isoflurane) and glucagon-like peptide-1 (GLP-1) in the protection from ischemia/reperfusion injury, we tested mice with isoflurane or exendine-4, GLP-1 agonist, and then exposed the mice to ischemia/reperfusion. Similar infarct size reductions were produced by treatment with isoflurane or exendine-4. The cardioprotective effects of these pharmacological preconditioning were abolished in GLP-1 antagonist pretreatment. Furthermore, apoptosis has been evaluated in these preconditionings and we found after 2 hours of reperfusion that apoptosis in myocardium at risk of ischemia is attenuated by preconditionings.
Additionally, to determine the downstream mediators of involved in isoflurane or GLP-1 preconditioning, we performed immunoblotting and realtime PCR using preconditioned samples.

Free Research Field

麻酔科学

URL: 

Published: 2016-06-03  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi