The effect of fosaprepitant, meurokinin-1 receptor antagonist, for the prevention of postoperative nausea and vomiting

2014 Fiscal Year Final Research Report

• Project/Area Number: 25861378
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: The University of Tokushima
• Principal Investigator: SOGA Tomohiro 徳島大学, ヘルスバイオサイエンス研究部, 特任助教 (20592538)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 制吐剤 / PONV / ニューロキニン１受容体

Outline of Final Research Achievements

This prospective, double-blind, randomized study comprised patients who underwent abdominal operations. They were randomly allocated to receive intravenous fosaprepitant (NK1) or ondansetron (ONS) before anesthesia. No patient in the NKI group experienced vomiting after surgery; 20-30 % patients in the ONS group experienced vomiting. This difference was significant (at 0-2 h, 2-24 h, 24-48 h, and 48-72 h). During the study period, no significant differences existed between the NK1 and ONS groups in the incidence of PONV, complete response rate, rescue antiemetic use, nausea score, and VAS score for pain.
Additionally, NK1 was more effective than ONS in decreasing the incidence of vomiting after lower limb surgery with postoperative opioid administration as well.

Free Research Field

麻酔科学