2014 Fiscal Year Final Research Report
Toll-like receptor might be involved into delayd onset paraplegia
| Project/Area Number |
25861383
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | Toll様受容体 / 遅発性脊髄障害 / 脊髄虚血 |
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| Outline of Final Research Achievements |
We investigated whether TLR4, TLR2, MyD88 or TRIF might be associated withonset of delayed paraplegia after spinal cord ischemia in mice. In our results, either TLR2 KO- or TRIF KO-mice could not show delayed paraplegia. In contrast, both TLR4 KO- and MyD88 KO-mice displayed delayed paraplegia after spinal cord ischemia. These results suggested that either TLR4 or MyD88 should be necessary in onset of delayed paraplegia after spinal cord ischemia.
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| Free Research Field |
麻酔科学
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