Elucidation of f drug-induced coronary artery spasm during pregnancy examined from gene single nucleotide polymorphism analysis

2016 Fiscal Year Final Research Report

• Project/Area Number: 25861395
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Wakayama Medical University
• Principal Investigator: TADASHI TANIOKU 和歌山県立医科大学, 医学部, 学内助教 (50554656)
• Research Collaborator: NAKAHATA Katsutoshi (70332971)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 遺伝子一塩基多型 / メチルエルゴメトリンマレイン酸塩

Outline of Final Research Achievements

When administering methyl ergometrine maleate which is frequently used during caesarean section operation, attention must be paid to the onset of coronary spasm. However, it is impossible for individual pregnant women to predict the presence or absence of side effects by methyl ergometrine maleate before drug administration. We attempted to elucidate individual differences in expression of side effects by the drug, paying attention to gene single nucleotide polymorphisms of genes expected to be involved in expression of methyl ergometrin maleate effect. We examined the gene single nucleotide polymorphism of patients scheduled for selective caesarean section and analyzed the relation with electrocardiogram ST change. However, the relationship between gene single nucleotide polymorphism and electrocardiogram ST change was not clarified.

Free Research Field

麻酔科学