2016 Fiscal Year Final Research Report
Does Aquaporin channel have an important role in cancer ascites?
| Project/Area Number |
25861398
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Research Collaborator |
Yasuhito Uezono
Kiyoshi Terawaki
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | がん性腹水 / アクアポリン / 胃がん細胞 |
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| Outline of Final Research Achievements |
Malignant peritonitis is one of the most intractable symptom of abdominal distension for cancer patients and it depends on amount of malignant ascites. However, it remains unclear the mechanism of production of malignant ascites. So we can hardly manage this symptom. We hypothesized that novel water channel "aquaporin" channel might have an important role in production of malignant ascites. The aim of this study was the proof of this hypothesis.
After we implanted 85As2 cells, which is derived from human gastric cancer and induces cancer peritonitis to mice, we observed that severe cancer acsites was observed, but we failed to prove the hypothesis.
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| Free Research Field |
緩和医療
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