2016 Fiscal Year Final Research Report
Experimental study of the glycosyltransferase as a drug target of bladder cancer
| Project/Area Number |
25861405
|
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| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
|
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| Research Institution | Hirosaki University |
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Principal Investigator |
|
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| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Keywords | 糖転移酵素 / 糖鎖生物学 |
|---|
| Outline of Final Research Achievements |
Cell surface carbohydrates expressed on epithelial cells are thought to play an important role in tumor progression. We previously showed Core2 beta-1,6-N-acetylglucosami-
nyltransferase expression in bladder cancer correlated with tumor progression. In this study, we tryed to inhibit the glycosyltransferase using imitation glucose. The imitation glucose showed specifically inhibition of tumor growth in vitro. Therefore, although further study is necessary to determine the glycosyltransferase as a drug target of cancer, imitation glucose has a potential of novel therapeutic agent.
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| Free Research Field |
泌尿器科学
|
