Identification of perineural invasion related molecule in prostate cancer using phage display screening

2016 Fiscal Year Final Research Report

• Project/Area Number: 25861407
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Hirosaki University
• Principal Investigator: Okamoto Akiko 弘前大学, 医学研究科, 研究員 (60436037)
• Co-Investigator(Renkei-kenkyūsha): Yoneyama Tohru 弘前大学, 医学研究科, 助教 (50587649)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 神経周囲浸潤

Outline of Final Research Achievements

Perineural invasion (PNI) is important mechanism for extra-capsular extension of prostate cancer (PC). In this study, we identified integrin α6 and laminin binding glycan (LNBG) on α-dystroglycan were important molecules for PNI of PC by using phage display screening and several molecular cell biologic analysis.
We found that LNBG expressing PC cells without expression of integrin α6 inhibited perineural invasion capacity, functioning as a tumor suppressor. Both LNBG depletion and up-regulation of integrin α6 of PC cells and activation of SDF-1-CXCR4 signaling requried by enhancement of perineural invasion capacity of PC cells.

Free Research Field

泌尿器腫瘍学