Maintenance of intratumoral androgens and possibility of personalized medicine in prostate cancer by using cancer tissue-originated spheroid method

2014 Fiscal Year Final Research Report

• Project/Area Number: 25861411
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Gunma University
• Principal Investigator: ARAI SEIJI 群馬大学, 医学部附属病院, 助教 (10636210)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 前立腺癌 / CRPC / CTOS法 / スフェロイド / アンドロゲン

Outline of Final Research Achievements

In this study, I tried to establish cancer tissue-originated spheroid (CTOS) from castration resistant prostate cancer (CRPC) tissues by using CTOS method. Unfortunately, however, it was impossible to make it probably due to the problems of tissue collections and an original feature of prostate cancer cells that is difficulties of establishment of primary culture from prostate cancer patient tissues. In CRPC tissues, DHEA-S was most existing androgens. Moreover, the DHEA-S concentrations in CRPC tissues were highly correlated with the serum DHEA-S concentrations, which suggest that supply of DHEA-S from serum is important for the maintenance of androgens in CRPC tissues.

Free Research Field

医歯薬学