2014 Fiscal Year Final Research Report
Investigation into the mechanism of interstitial cystitis and new therapeutic drug candidate GsMTX4
| Project/Area Number |
25861414
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
OOTAKE Yuuko 山梨大学, 総合研究部, 診療助教 (80631449)
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| Research Collaborator |
MIYAMOTO Tatsuya 山梨大学, 総合研究部, 助教 (80456459)
TAKEDA Masayuki 山梨大学, 総合研究部, 教授 (80197318)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 間質性膀胱炎 |
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| Outline of Final Research Achievements |
We examined the expression of h-TRPC1, h-TRPC6 and h-TRPV4 mRNAs in the bladder urothelium of interstitial cystitis patients by quantitative RT-PCR.In addition, we examined the correlation between IC symptom score and each TRP channels.
The mouse metabolic cage experiment showed that administration of GsMTx4 decreased urinary frequency and increased urine volume/voided urine in mice, despite there being no changes in water intake and total urine volume. This indicates that GsMTx4 is effective in urine storage function.
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| Free Research Field |
排尿生理
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