2015 Fiscal Year Final Research Report
Functional analysis of TAp63alpha-Bnc1 signal in oocyte
| Project/Area Number |
25861462
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Research Collaborator |
IHARA Motomasa
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 生殖 / 卵成熟 |
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| Outline of Final Research Achievements |
Basonuclin1 (Bnc1) gene is specifically expressed in germ cells and keratinocyte. We have focused on the mechanism to regulate Bnc1 expression level in mouse GV stage oocyte. Microinjection of TAp63 alpha mRNA into mature GV stage oocytes did not increase the Bnc1 gene expression. Using Mass Spectrography, We have identified the novel Bnc1-binding proteins and possibility that TAp63 alpha gene expression is regulated by Bnc1 and a novel Bnc1-binding protein“X”.
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| Free Research Field |
生殖医学
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