2014 Fiscal Year Final Research Report
ADAR1 induced somatic hypermutation in ovarian endometriosis
Project/Area Number |
25861470
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Obstetrics and gynecology
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Research Institution | Chiba University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Keywords | 体細胞突然変異 / 卵巣がん |
Outline of Final Research Achievements |
Ovarian cancer does occur at higher than expected rates in women with endometriosis. ARID1A and c-myc have high frequent mutations in ovarian clear cell carcinoma. The RNA editor gene ADAR1 is induced by inflammatory ligands and buffers stress response. The ADAR1 gene was overexpressed in endometriosis and ovarian clear cell carinoma cells.Exogenous ADAR1 induced adenosine-targeted DNA mutations in the ARID1A gene and the c-myc gene of wild-type mouse embryonic fibroblasts (MEFs) which have γ-H2AX expression.
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Free Research Field |
産婦人科学
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