Search for the New Molecular Targeted Therapies Based on Genetic Profiles of Ovarian Clear Cell Carcinoma

2015 Fiscal Year Final Research Report

• Project/Area Number: 25861473
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: The University of Tokyo
• Principal Investigator: UEHARA YURIKO 東京大学, 医学部附属病院, 登録研究医 (50648433)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 卵巣明細胞腺癌 / 染色体コピー数解析 / 遺伝子発現解析 / クラスター解析 / ARID1A / PIK3CA

Outline of Final Research Achievements

Among various histological subtypes of epithelial oarian cancer, ovarian clear cell carcinoma is generally chemoresistant and associated with poor clinical outcome even at an early stage. Therfore, biomarkers to predict the prognosis of clear cell carcinoma and the development of novel molecular tarfeted therapies, on the basis of these biomarkers, are warranted.
In this study, we performed single nucleotide polymorphism analysis with clinical samples of ovarian cancer and evaluated the relationships between chromosomal instability and histological subtypes. Then, we performed microarray gene expression profiling and analyzed three subtypes defined with hierarchical clustering of the gene expression data. We further subclassified the clinical samples of clear cell carcinoma by gene expression profiling, and extracted the gene expression profiles and the signal pathway which might be associated with prognosis and chemoresistance of ovarian clear cell carcinoma.

Free Research Field

産婦人科学