2014 Fiscal Year Final Research Report
The functional analysis of LKB1-AMPK system in the estrogen responsive organs
| Project/Area Number |
25861475
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Research Institute, International Medical Center of Japan |
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Principal Investigator |
HAJIME Oishi 独立行政法人国立国際医療研究センター, その他部局等, その他 (40401088)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | AMPK / SIRT3 / 卵巣 / 顆粒膜細胞 |
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| Outline of Final Research Achievements |
The aim of the study is to clarify the involvement of the LKB1-AMPK system in the estrogen responsive organs such as ovary, uterus, and mammary gland. The LKB1 phosphorylates AMPK1, which controls and senses energy balance in the cell. The regulation of both steroidogenesis and cell proliferation by energy sensing system were examined in these organs. We also investigated the function of SIRT3, one of the interacting factor of AMPK, in the ovary. The biosynthesis of progesterone is found to be regulated by SIRT3.
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| Free Research Field |
生殖内分泌
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