2015 Fiscal Year Final Research Report
Development of stem cell differentiation technology into steroidogenic cells with epigenetic regulation
| Project/Area Number |
25861481
|
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | University of Fukui |
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Principal Investigator |
|
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | LRH-1 / SF-1 / PGC-1α / 卵巣顆粒膜細胞 / 黄体ホルモン / 黄体化 |
|---|
| Outline of Final Research Achievements |
In this study, we revealed that the ovarian granulosa cell specific promoter region of LRH-1 is controlled by the transcription factor SF-1 and PGC-1α in a coordinated fashion. Our results suggest that the expression of genes involved in progesterone biosynthesis is under the control of ovarian LRH-1 via SF-1 in human ovarian granulosa cells.
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| Free Research Field |
医師薬学
|
