2015 Fiscal Year Final Research Report
histological diagnosis of amniotic fluid embolism using immunostaining of zinc coproporphyrin1
| Project/Area Number |
25861485
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
Furuta Naomi 浜松医科大学, 医学部附属病院, 助教 (80647595)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 胎便 / 胎盤 / 抗亜鉛コプロポルフィリン抗体 |
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| Outline of Final Research Achievements |
Immunoreactivity of ZnCP-Ⅰ clearly and specifically identified meconium in the placenta,fetal membrane,and umbilical cord.Meconium was detected in clear amniotic fluid at delivery, especially in cases of premature rupture of membrane,suggesting previous exposure.We suggested that the meconium effect at onset of labor as a signal of the fetal maturation.Immunohistochemical detection of ZnCP-I is a highly sensitive histological diagnosis .Clear immunostaining of ZnCP-Ⅰwas detected in the lung tissues. In cases of acute or subacute exposure to meconium, ZnCP-I immunostainning was obsterved in dependent of macrophage-specific CD68. By contrast, ZnCP-I and CD68 was obserbed in the identical cells at the case of chronic exposure to meconium. Monoclonal antibody for ZnCP-Ⅰ would be useful to establish the histological diagnostic criteria for the lung of meconium aspiration syndrome.
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| Free Research Field |
周産期
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