2014 Fiscal Year Final Research Report
Development of a new drug for ovulation induction targeted to central nervous system
| Project/Area Number |
25861487
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Research Collaborator |
IWASE Akira 名古屋大学, 大学院医学系研究科, 病院教授 (20362246)
GOTO Maki 名古屋大学, 大学院医学系研究科, 講師 (90378125)
KONDO Mika 名古屋大学, 大学院医学系研究科
OSUKA Satoko 名古屋大学, 大学院医学系研究科
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 多嚢胞性卵巣症候群 / キスペプチン / パルス状LH分泌 |
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| Outline of Final Research Achievements |
PCOS (polycystic ovary syndrome) is a condition that causes irregular menstrual periods and infertility. It has been suggested that abnormal pulsatile secretion of GnRH and LH is one of the causes of PCOS. Recently, it has been suggested the possibility that kisspeptin, a kind of neuropeptide, control GnRH secretion within the hypothalamus. Based on these background, we aimed to develop a new drug for ovulation induction targeted to central nervous system.
By using the PCOS animal model, we found the possibility of a relationship between abnormal feedback mechanism of progesterone secretion within the hypothalamus and abnormal pulsatile GnRH and LH secretion. Control the feedback mechanism of progesterone secretion within the hypothalamus may become a drug target for PCOS.
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| Free Research Field |
不妊生殖内分泌学
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