Induction of Mn-SOD by cAMP is associated with histone acetylation status aof the C/EBPb binding site of their promoters in human endometrial stromal cells.

2014 Fiscal Year Final Research Report

• Project/Area Number: 25861495
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Yamaguchi University
• Principal Investigator: TAMURA Isao 山口大学, 医学部附属病院, 助教 (40610663)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 子宮内膜 / 脱落膜化 / エピジェネティクス

Outline of Final Research Achievements

This study showed the new molecular mechanisms by which C/EBPｂ up-regulates the expression of Mn-SOD in human endometrial stromal cell (ESC). The enhancer region of Mn-SOD gene show high histone acetylation status, which may contribute to form the loose chromatin structure so that C/EBPb can easily acces to the DNA binding site. In human ESC, Mn-SOD gene expression is regulated by epigenetic mechanisms.

Free Research Field

生殖内分泌学