2014 Fiscal Year Final Research Report
PTEN protein expression and gene alteration as a diagnostic tool for earliest endometrial cancer
| Project/Area Number |
25861505
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 子宮内膜癌 / PTEN / Liquid-based cytology / 免疫細胞化学 / FISH |
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| Outline of Final Research Achievements |
To establish the accurate diagnostic tool for the endometrial cancer, we analyzed the PTEN protein expression and gene loss of endometrial carcinoma using liquid-based cytology（LBC）. PTEN protein expression was decreased in endometrial cancer compared to normal and endometrial hyperplasia. FISH assessment for PTEN gene in LBC slide needs the pretreatment to detect the clear fluorescent signal. We are considering a new protocol to detect a stable fluorescence signal in LBC slides.
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| Free Research Field |
細胞診断学
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