2015 Fiscal Year Final Research Report
The roles and clinical significance of microRNAs in cervical cancer.
| Project/Area Number |
25861506
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 子宮頸癌 / micro RNA / 細胞増殖 |
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| Outline of Final Research Achievements |
Using the same cervical cancer patient's serum obtained at 2 points – before treatment and after treatment, we identified microRNAs to be highly expressed in cervical cancer. Micro RNAs that were equal to or greater than 4 times before treatment was 12. Out of these 12 micro RNAs, miR-1246, miR-4306 and miR-1290 were identified. These three micro RNA was novel micro RNAs, these has not been reported in cervical cancer. Proliferating assay revealed that miR-1290 was involved in cell proliferation. miR-1290 there is likely to be involved in the malignant transformation of cervical cancer.
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| Free Research Field |
子宮頸癌
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