2015 Fiscal Year Final Research Report
Alteration of villous DNA methylation associated with fetal growth resriction
| Project/Area Number |
25861510
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Showa University |
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Principal Investigator |
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| Research Collaborator |
KOIDE Keiko 昭和大学, 医学部, 講師 (90384437)
SEKIZAWA Akihiko 昭和大学, 医学部, 教授 (10245839)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 胎児発育 / 胎盤 / DNAメチル化 |
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| Outline of Final Research Achievements |
Villous DNA methylation profiles in dichorionic diamniotic twins were analyzed.
123 CpG sites were extracted as CpG site whose DNA methylation status altered in fetus with fetal growth restriction compared with the twin sibling grew up normally and was not significantly different in the twin siblings who both grew up normally. It was suggested that the alteration of villous DNA methylation at the CpG sites extracted in this study were associated with the pathogenesis of fetal growth restriction.
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| Free Research Field |
医歯薬学
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